Exaggerated Delayed-Type Hypersensitivity to Simple Chemical Allergens in the Guinea Pig*
نویسندگان
چکیده
منابع مشابه
THE EFFECT OF ASCORBIC ACID ON BLOOD HISTAMINE LEVEL AND DELAYED-TYPE HYPERSENSITIVITY IN GUINEA PIGS
The effect of ascorbic acid on blood histamine level and delayed-type hypersensitivity was studied in thirty male guinea pigs. Animals were sensitized to B.C.G., trichophytin and mallein during the first four weeks. The diet was ad libitum during this period. After this "sensitization period" animals w er e tested intradermally with tuberculin, trichophytin and mallein. The number and diam...
متن کاملDelayed-type hypersensitivity responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the guinea pig.
Two antigens from Mycobacterium tuberculosis, ESAT-6 and MPT64, elicited delayed-type hypersensitivity (DTH) skin responses in outbred guinea pigs infected with M. tuberculosis by the aerosol and intravenous routes but not those sensitized with M. bovis BCG or M. avium. The DTH epitope of ESAT-6 was mapped to the C terminus. Nonresponders to the individual antigens were found, but all animals r...
متن کاملEvaluation of Mycobacterium tuberculosis specific RD antigens for delayed type hypersensitivity responses in guinea pig.
Tuberculin skin test (TST), an age old method is based on measuring delayed-type hypersensitivity (DTH) response to purified protein derivative (PPD). However, inspite of simplicity, ease and cost effectiveness, the usefulness of PPD test is limited due to its inability to distinguish among a protective immune response, latent infection and active tuberculosis disease. On the other hand, a skin...
متن کاملExaggerated Delayed Hypersensitivity to Mosquito Bites in Chronic Lymphocytic Leukemia.
I T IS THE PURPOSE of this report to describe the occurrence of unusual cutaneous hyper-reactivity phenomena in certain patients having chronic lymphocytic leukemia. These reactions are consistent with an exaggerated delayed hypersensitivity type of response to insect bites, inoculated mosquito antigen and to certain other delayed hypersensitivity antigens. The mosquito is an example of certain...
متن کاملMechanisms in the Suppression of Delayed Hypersensitivity in the Guinea Pig by 6-mercaptopurine
The mechanism of suppression, of delayed hypersensitivity to tuberculoprotein by 6-mercaptopurine (6-MP) was studied in guinea pigs. Under the conditions of the protocol, suppression of tuberculin delayed skin test reactivity was not associated with a significantly altered end-organ response to mediators of permeability. No significant alteration of in vivo lymphoid activity, as measured by rec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1967
ISSN: 0022-202X
DOI: 10.1038/jid.1967.166